We used the genetic algorithm (GA) and two-dimensional blood flow analysis to examine the fluid dynamic and engineering factors in multi-objective optimization of blood tubes (vessels). We supposed two factors from fluid dynamics: the wall shear stress (WSS) and the pressure loss, and one materials saving factor: the artery length. As a result, we could get the optimum shapes for each factor. In the case of WSS and artery length, both smoothly curved artery shapes and shapes with bulges were obtained as lower WSS cases. The shapes with bulges were similar to those of aneurysms. In this case, it was found that the WSS increases after the bulge is removed. This means bulges in artery vessel areas with higher WSSs effectively reduce the WSS value. Only the case of WSS and artery length produced a shape like an aneurysm. These results indicate that WSS and artery length are significant factors in determining artery shape.

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