In order to improve the cavitation resistance of centrifugal pump, bionic groove surface structure was arranged on the suction surface of centrifugal pump blade which is the most prone to cavitation. Numerical simulation method was used to study the influence of different-shape groove blade on cavitation performance of centrifugal pump. The results showed that the head and efficiency of the centrifugal pump with circular grooved surface blades were close to the smooth surface blade centrifugal pump and higher than those with triangular grooved surface blades and rectangular grooved surface blades. The low pressure area of the circular groove blade was the smallest and the cavitation resistance was the best. At the critical cavitation margin point, circular groove blade can effectively reduce the probability of negative incidence, and the cavitation inhibition effect was the most obvious.