The computational domain is one of the major factors inducing CFD uncertainty. The effects of different computational domains and several key issues on CFD simulation results for centrifugal pumps are studied, such as the effects of modeling methods and boundary conditions on the whole computational domain numerical simulation. The study results indicate that the prediction accuracy of the whole computational domain is higher than that of the non-whole computational domain. The velocity distribution obtained by the whole computational domain in the gap between the impeller and volute is significantly layered, while the distribution obtained by the non-whole computational domain is triangular. The relative velocity distribution in the impeller and the turbulent kinetic energy in the volute for the two computational domains are obviously different, too. The number of the interfaces has little impact on the prediction accuracy. The rotational attribute of the chamber wall has a little effect on velocity and turbulent kinetic energy distribution, but the rotational attribute of the chamber wall can significantly improve the prediction accuracy of efficiency.

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