Indoor air quality (IAQ) is nowadays universally recognized as an important issue that affects the comfort and health of people, as well as their productivity. This paper describes the relationship of indoor CO2 concentration to building air quality and ventilation, with a focus on how CO2 can be used to evaluate and predict air quality and ventilation performance, namely the infiltration airflow rate. Besides it shows the ability of ESP-r building simulation software for predicting the CO2 concentration and the air exchange rate in a building. For this purposes a room of a hotel located in the urban area of Coimbra was chosen. The developed simulation model was then validated against empirical results. It was shown that a fair degree of agreement between ESP-r results and the experimental observation exist for the zones. High accuracy of the simulation model showed that building simulation software, namely ESP-r can provide a better understanding of indoor environmental conditions and be a powerful tool in finding the best modification measures for improving the indoor air quality in a building.

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