In order to perform the drug delivery via lung, tracking the trajectories of fine inhaled particles in the acinar airways is of high importance. The causes of irreversibility in the motion of fine particles (0.1–1 micron) and chaotic flow deep in the acinar region of lung has been always under investigation. In this study we demonstrate the importance of geometric hystersis and asynchrony of lung deformation on the issue. We adapted a 2D axisymmetric geometry of alveolated duct from recent relative works and deformed it in a way that some hystersis would appear in a respiration period. The overall deformation of duct was corresponding to the transpulmonary pressure of lung reported in physiological books and the Re number was matched with the actual flow in acinar airways. The geometric hystersis had the same amount as the measured hystersis in rat lungs available in relative literature. We performed a lagrangian particle tracking for different cases with and without geometric hystersis. Results confirm that as soon as some asynchrony appears in wall motion the trajectories of particles become extremely irreversible and hence we propose that the geometric hystersis can be a principal reason for observed irreversibility in acinar airways.
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ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis
July 12–14, 2010
Istanbul, Turkey
Conference Sponsors:
- International
ISBN:
978-0-7918-4915-6
PROCEEDINGS PAPER
Effects of Geometric Hystersis in Lung Deformation on Irreversibility in Trajectories of Fine Inhaled Particles
Mohsen Zendehbad,
Mohsen Zendehbad
Sharif University of Technology, Tehran, Iran
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Mohammad S. Saidi,
Mohammad S. Saidi
Sharif University of Technology, Tehran, Iran
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Mahdi Sani
Mahdi Sani
Sharif University of Technology, Tehran, Iran
Search for other works by this author on:
Mohsen Zendehbad
Sharif University of Technology, Tehran, Iran
Mohammad S. Saidi
Sharif University of Technology, Tehran, Iran
Mahdi Sani
Sharif University of Technology, Tehran, Iran
Paper No:
ESDA2010-25116, pp. 789-796; 8 pages
Published Online:
December 28, 2010
Citation
Zendehbad, M, Saidi, MS, & Sani, M. "Effects of Geometric Hystersis in Lung Deformation on Irreversibility in Trajectories of Fine Inhaled Particles." Proceedings of the ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis. ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis, Volume 1. Istanbul, Turkey. July 12–14, 2010. pp. 789-796. ASME. https://doi.org/10.1115/ESDA2010-25116
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