The present work is part of a larger project to analyse adaptive bone remodelling around implants that receive controlled mechanical stimulation immediately post-operatively. Percutaneous implants in the tibiae of guinea pigs are used as an implant model [1]. For evaluation, microfocus computed tomography (μCT) can be used to complement or partially substitute conventional histology [2]. In the studied model implant system, μCT-based histomorphometry can be used as a substitute for histology in regions at a distance of more than 1000 μm from the titanium implant. Within this limitation, a significant effect of mechanical stimulation can be observed also under in vivo μCT conditions. The optimally osteogenic stimulus in the studied model should cause a strain rate amplitude of 1600 microstrain/s or less in the cortical bone at a distance of 2.3 mm from the implant centre. Future work will include a detailed study of strains in the peri-implant bone with in vivo micro CT-based finite element models.
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ASME 7th Biennial Conference on Engineering Systems Design and Analysis
July 19–22, 2004
Manchester, England
ISBN:
0-7918-4174-X
PROCEEDINGS PAPER
Peri-Implant Bone Adaptation Under Dynamic Mechanical Stimulation: The Guinea Pig Model Available to Purchase
Siegfried V. N. Jaecques,
Siegfried V. N. Jaecques
Katholieke Universiteit Leuven, Leuven, Belgium
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Els De Smet,
Els De Smet
Katholieke Universiteit Leuven, Leuven, Belgium
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Luiza Muraru,
Luiza Muraru
Katholieke Universiteit Leuven, Leuven, Belgium
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John A. Jansen,
John A. Jansen
University Medical Center Nijmegen, Nijmegen, The Netherlands
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Martine Wevers,
Martine Wevers
Katholieke Universiteit Leuven, Leuven, Belgium
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Jos Vander Sloten,
Jos Vander Sloten
Katholieke Universiteit Leuven, Leuven, Belgium
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Ignace E. Naert
Ignace E. Naert
Katholieke Universiteit Leuven, Leuven, Belgium
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Siegfried V. N. Jaecques
Katholieke Universiteit Leuven, Leuven, Belgium
Els De Smet
Katholieke Universiteit Leuven, Leuven, Belgium
Luiza Muraru
Katholieke Universiteit Leuven, Leuven, Belgium
John A. Jansen
University Medical Center Nijmegen, Nijmegen, The Netherlands
Martine Wevers
Katholieke Universiteit Leuven, Leuven, Belgium
Jos Vander Sloten
Katholieke Universiteit Leuven, Leuven, Belgium
Ignace E. Naert
Katholieke Universiteit Leuven, Leuven, Belgium
Paper No:
ESDA2004-58582, pp. 589-595; 7 pages
Published Online:
November 11, 2008
Citation
Jaecques, SVN, De Smet, E, Muraru, L, Jansen, JA, Wevers, M, Vander Sloten, J, & Naert, IE. "Peri-Implant Bone Adaptation Under Dynamic Mechanical Stimulation: The Guinea Pig Model." Proceedings of the ASME 7th Biennial Conference on Engineering Systems Design and Analysis. Volume 2. Manchester, England. July 19–22, 2004. pp. 589-595. ASME. https://doi.org/10.1115/ESDA2004-58582
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