Solar-powered organic Rankine cycle (ORC) is a promising technology and has the potential to provide clean electric energy. Extensive studies on the design of ORC systems have been conducted and reported in the literature. However, very few studies have presented the influence of the climate zones on the performance of a solar-powered ORC, especially for an integrated ORC and energy storage system. This paper presents an analysis to determine the performance of a solar-powered ORC with electric energy storage (EES) to supply electricity to a building in different climate zones in the United States. The building type evaluated in this paper is a large office, and the energy consumption of the facility in each climate location was determined using EnergyPlus. The ORC-EES operational strategy used in this investigation consists of the ORC charging the EES when solar irradiation is sufficient to generate power. Then the EES provides power to the building when there is no solar energy available. The ORC-EES is evaluated based on the potential to reduce the operational cost, the primary energy consumption, and the carbon dioxide emission. Furthermore, the effect of the number of solar collectors and the EES size on the performance of the ORC-EES system is also studied.