Electroporation is an effective means to deliver molecules into the cellular cytoplasm, and has been widely applied in both biological research and clinical applications. The process however suffers from low viability and efficiency. In this work, we present a multi-pulse feedback control scheme for enhancing viability and efficiency of electroporation process. We first present a spherical model for cell transmembrane potential (TMP) dynamics to describe the spatial distribution of electric potential on cell membrane. Then we analyze the models and discuss the bifurcation property of the system. Based on the dynamic models, we design a nonlinear model predictive controller (NMPC) to track pore size profiles in electroporation. We demonstrate that by using NMPC, the pore size can be precisely regulated to targeted values for drug delivery applications. The control design is illustrated through simulation examples.
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ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control
October 31–November 2, 2011
Arlington, Virginia, USA
Conference Sponsors:
- Dynamic Systems and Control Division
ISBN:
978-0-7918-5476-1
PROCEEDINGS PAPER
Spherical Modeling and Nonlinear Model Predictive Control of Electroporation
Jingang Yi,
Jingang Yi
Rutgers, The State University of New Jersey, Piscataway, NJ
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Jianbo Li,
Jianbo Li
Rutgers, The State University of New Jersey, Piscataway, NJ
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Hao Lin
Hao Lin
Rutgers, The State University of New Jersey, Piscataway, NJ
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Jingang Yi
Rutgers, The State University of New Jersey, Piscataway, NJ
Jianbo Li
Rutgers, The State University of New Jersey, Piscataway, NJ
Hao Lin
Rutgers, The State University of New Jersey, Piscataway, NJ
Paper No:
DSCC2011-5984, pp. 545-552; 8 pages
Published Online:
May 5, 2012
Citation
Yi, J, Li, J, & Lin, H. "Spherical Modeling and Nonlinear Model Predictive Control of Electroporation." Proceedings of the ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control. ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, Volume 2. Arlington, Virginia, USA. October 31–November 2, 2011. pp. 545-552. ASME. https://doi.org/10.1115/DSCC2011-5984
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