Electroporation is an effective means to deliver molecules into the cellular cytoplasm, and has been widely applied in both biological research and clinical applications. The process however suffers from low viability and efficiency. In this work, we present a multi-pulse feedback control scheme for enhancing viability and efficiency of electroporation process. We first present a spherical model for cell transmembrane potential (TMP) dynamics to describe the spatial distribution of electric potential on cell membrane. Then we analyze the models and discuss the bifurcation property of the system. Based on the dynamic models, we design a nonlinear model predictive controller (NMPC) to track pore size profiles in electroporation. We demonstrate that by using NMPC, the pore size can be precisely regulated to targeted values for drug delivery applications. The control design is illustrated through simulation examples.

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