Toxoplasma gondii is a protozoan capable of replicating sexually in cats and asexually in other warm-blooded animals. By using a three dimensional mesh of both the brain and spleen, it is possible to simulate using a computational model to demonstrate the entire life-cycle within an intermediate host of the parasite as it completes the life-cycle using host cells of these organs. A cellular automata model is developed to demonstrate the dynamics of the parasite, where each cell follows the same set of rules for each discrete time-step. This cellular automata model allows for data simulations to be run of the parasite within a mouse and display graphical images and animations.
- Dynamic Systems and Control Division
Mathematical Modeling of Within-Host Dynamics of Toxoplasma Gondii
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Sullivan, A, Zhao, X, & Su, C. "Mathematical Modeling of Within-Host Dynamics of Toxoplasma Gondii." Proceedings of the ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control. ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, Volume 2. Arlington, Virginia, USA. October 31–November 2, 2011. pp. 527-529. ASME. https://doi.org/10.1115/DSCC2011-6133
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