Magnetic Resonance Imaging (MRI) guided nanorobotic systems that could perform diagnostic, curative and reconstructive treatments in the human body at the cellular and sub-cellular level in a controllable manner have recently been proposed. The concept of a MRI-guided nanorobotic system is based on the use of a MRI scanner to induce the required external driving forces to guide magnetic nanocapsules to a specific target. However, the maximum magnetic gradient specifications of existing clinical MRI systems are not capable of driving superparamagnetic nanocapsules against the blood flow and therefore these MRIs do not allow for navigation. The present paper proposes a way to overcome this critical drawback through the formation of micron size agglomerations where their size can be regulated by external magnetic stimuli. This approach is investigated through modeling of the physics that govern the self-assembly of the nanoparticles. Additionally a computational tool has been developed that incorporates the derived models and performs simulation, visualization and post-processing analysis. Preliminary simulation results demonstrate that external magnetic field causes aggregation of nanoparticles while they flow in the vessel. This is a promising result — in accordance with similar experimental results — and encourages further investigation on the nanoparticle based self-assembly structures for use in nanorobotic drug delivery.
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ASME 2010 Dynamic Systems and Control Conference
September 12–15, 2010
Cambridge, Massachusetts, USA
Conference Sponsors:
- Dynamic Systems and Control Division
ISBN:
978-0-7918-4418-2
PROCEEDINGS PAPER
Computational Studies of Controlled Nanoparticle Agglomerations for MRI-Guided Nanorobotic Drug-Delivery Systems
Panagiotis Vartholomeos,
Panagiotis Vartholomeos
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
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Suleyman S. Aylak,
Suleyman S. Aylak
Northeastern University, Boston, MA
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Constantinos Mavroidis
Constantinos Mavroidis
Northeastern University, Boston, MA
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Panagiotis Vartholomeos
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Suleyman S. Aylak
Northeastern University, Boston, MA
Constantinos Mavroidis
Northeastern University, Boston, MA
Paper No:
DSCC2010-4245, pp. 73-80; 8 pages
Published Online:
January 25, 2011
Citation
Vartholomeos, P, Aylak, SS, & Mavroidis, C. "Computational Studies of Controlled Nanoparticle Agglomerations for MRI-Guided Nanorobotic Drug-Delivery Systems." Proceedings of the ASME 2010 Dynamic Systems and Control Conference. ASME 2010 Dynamic Systems and Control Conference, Volume 2. Cambridge, Massachusetts, USA. September 12–15, 2010. pp. 73-80. ASME. https://doi.org/10.1115/DSCC2010-4245
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