Cell migration is fundamental to a wide range of biological and physiological functions including: wound healing, immune defense, cancer metastasis, as well as the formation and development of biological structures such as vascular and neural networks. In these diverse processes, cell migration is influenced by a broad set of external mechanical and biochemical cues, particularly the presence of (time dependent) spatial gradients of soluble chemoattractants in the extracellular domain. Many biological models have been proposed to explain the mechanisms leading to the migratory response of cells as a function of these external cues. Based on such models, here we propose approaches to controlling the chemotactic response of eukaryotic cells by modulating their micro-environments in vitro (for example, using a microfluidic chemotaxis chamber). By explicitly modeling i) chemoattractant-receptor binding kinetics, ii) diffusion dynamics in the extracellular domain, and iii) the chemotactic response of cells, models for the migration processes arise. Based on those models, optimal control formulations are derived. We present simulation results, and suggest experimental approaches to controlling cellular motility in vitro, which can be used as a basis for cellular manipulation and control.
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ASME 2010 Dynamic Systems and Control Conference
September 12–15, 2010
Cambridge, Massachusetts, USA
Conference Sponsors:
- Dynamic Systems and Control Division
ISBN:
978-0-7918-4417-5
PROCEEDINGS PAPER
Control of Eukaryotic Cell Migration Through Modulation of Extracellular Chemoattractant Gradients Available to Purchase
Waleed A. Farahat,
Waleed A. Farahat
Massachusetts Institute of Technology, Cambridge, MA
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H. Harry Asada
H. Harry Asada
Massachusetts Institute of Technology, Cambridge, MA
Search for other works by this author on:
Waleed A. Farahat
Massachusetts Institute of Technology, Cambridge, MA
H. Harry Asada
Massachusetts Institute of Technology, Cambridge, MA
Paper No:
DSCC2010-4190, pp. 397-404; 8 pages
Published Online:
January 25, 2011
Citation
Farahat, WA, & Asada, HH. "Control of Eukaryotic Cell Migration Through Modulation of Extracellular Chemoattractant Gradients." Proceedings of the ASME 2010 Dynamic Systems and Control Conference. ASME 2010 Dynamic Systems and Control Conference, Volume 1. Cambridge, Massachusetts, USA. September 12–15, 2010. pp. 397-404. ASME. https://doi.org/10.1115/DSCC2010-4190
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