In prior work, we have shown that just as in many engineering systems, impedance-like effects appear at the interconnection of biomolecular systems. These effects are called retroactivity, to extend the notion of impedance to biological systems. Signaling components, such as covalent modification cycles, play a central role in the transmission of signals within a cell and from outside the cell. They are typically found in highly interconnected architectures in which a component has several downstream clients. In this paper, we show that retroactivity from downstream targets decreases the sensitivity of response to an input stimulus.
- Dynamic Systems and Control Division
The Impact of Retroactivity on the Input/Output Static Characteristics of a Signaling Component
- Views Icon Views
- Share Icon Share
- Search Site
Ventura, AC, Jiang, P, Ninfa, AJ, Van Wassenhove, L, Merajver, SD, & Del Vecchio, D. "The Impact of Retroactivity on the Input/Output Static Characteristics of a Signaling Component." Proceedings of the ASME 2010 Dynamic Systems and Control Conference. ASME 2010 Dynamic Systems and Control Conference, Volume 1. Cambridge, Massachusetts, USA. September 12–15, 2010. pp. 313-320. ASME. https://doi.org/10.1115/DSCC2010-4061
Download citation file: