A transporting mechanism is designed for a micro total analysis system to move samples and reagents through microchannels that connect unit procedure components in the system. This study presents control design based on the 8051 microprocessor and implementation of biochip system comprising a pneumatic pumping actuator, feedback-signal photodiodes, and flowmeter. The new microfluid management technique successfully improved the efficiency of molecular biology reaction by increasing the velocity of the target nucleic acid molecules, which increases the effective collision into the probe molecules as the target molecules flow back and forth. Therefore, this hybridization chip is able to increase hybridization signal 6-fold and reduce non-specific target-probe binding and background noises within 30 minutes.
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ASME 2008 Dynamic Systems and Control Conference
October 20–22, 2008
Ann Arbor, Michigan, USA
Conference Sponsors:
- Dynamic Systems and Control Division
ISBN:
978-0-7918-4335-2
PROCEEDINGS PAPER
Microfluidic Manipulation in Biochip System Available to Purchase
Bor-Jiunn Wen,
Bor-Jiunn Wen
Industrial Technology Research Institute, Hsinchu, Taiwan, R.O.C.
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Yung-Chiang Chung,
Yung-Chiang Chung
Ming Chi University of Technology, Taishan, Taiwan, R.O.C.
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Tzong-Shi Liu
Tzong-Shi Liu
National Chiao Tung University, Hsinchu, Taiwan, R.O.C.
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Bor-Jiunn Wen
Industrial Technology Research Institute, Hsinchu, Taiwan, R.O.C.
Yung-Chiang Chung
Ming Chi University of Technology, Taishan, Taiwan, R.O.C.
Tzong-Shi Liu
National Chiao Tung University, Hsinchu, Taiwan, R.O.C.
Paper No:
DSCC2008-2136, pp. 253-258; 6 pages
Published Online:
June 29, 2009
Citation
Wen, B, Chung, Y, & Liu, T. "Microfluidic Manipulation in Biochip System." Proceedings of the ASME 2008 Dynamic Systems and Control Conference. ASME 2008 Dynamic Systems and Control Conference, Parts A and B. Ann Arbor, Michigan, USA. October 20–22, 2008. pp. 253-258. ASME. https://doi.org/10.1115/DSCC2008-2136
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