Abstract
The objective of this study is to investigate the rolling dynamics of leukocytes in microchannel flows using a hybrid continuum-particle approach. Leukocytes play an essential role in the immune system, and their margination behavior has been extensively studied both experimentally and numerically. In this study, we have developed a series of numerical experiments using a hybrid DPD-CFD solver with the membrane stiffness of the modeled leukocytes as the primary investigation subject. Our results show that increasing the stiffness of the cell's membrane influences its deformability and trajectory in microchannel flows. The results obtained from this study could be valuable in designing next-generation micro-carriers for targeted drug delivery systems, which mimic the margination behavior of leukocytes.
