Due to the anatomical and physiological similarities to humans that include similar heart size, flow rate, skin, liver enzymes and bone healing, porcine models as a powerful investigational platform have been widely used in research areas such as diabetes, obesity and islet transplantation [1]. The advantages of relative low cost, ease in handling and comparatively short period of breeding time may make swine provide a promising solution to the shortage of human donors and difficulty in isolating purified islets from adult human in future. Porcine cytokines play a significant role in innate immunity, apoptosis, angiogenesis, cell growth and differentiation. They are involved in cellular responses, maintenance of homeostasis, and disease states such as inflammatory disease, cardiovascular disease, and cancer. Thus, the technologies to analyze the expression of cytokines are developed rapidly and are still hot topics. The traditional approach for cytokine detection and quantification is the use of an enzyme-linked immunosorbent assay (ELISA). However, its inability to do multiplex test calls for more robust detection system. Biochip-based assay for the detection of biological agents using giant magnetoresistive (GMR) sensors and magnetic nanoparticles have emerged recently [2, 3]. It is proved that the nanomagnetic biosensor technology has advantages of low cost, high sensitivity, multiplexity, and real-time signal readout. The integration of GMR biosensor and use of weak magnetic fields allow to eventually realize point-of-care and portability. In addition, interferon gamma (IFNγ) is one of the most important porcine cytokines, and is associated with a number of autoinflammatory and autoimmune diseases. In this work, IFNγ is selected as a model target for the detection of porcine cytokine using nanomagnetic GMR biosensor.
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2017 Design of Medical Devices Conference
April 10–13, 2017
Minneapolis, Minnesota, USA
ISBN:
978-0-7918-4067-2
PROCEEDINGS PAPER
Nanomagnetic Biosensor for the Detection of Porcine Interferon Gamma Free
Hamada A. Aboubakr,
Hamada A. Aboubakr
University of Minnesota, St. Paul, MN
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James Vang,
James Vang
Zepto Life Technology, LLC, St. Paul, MN
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Victor Brenk,
Victor Brenk
Zepto Life Technology, LLC, St. Paul, MN
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Sagar M. Goyal,
Sagar M. Goyal
University of Minnesota, St. Paul, MN
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James Collins
James Collins
University of Minnesota, St. Paul, MN
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Wei Wang
University of Minnesota, St. Paul, MN
Hamada A. Aboubakr
University of Minnesota, St. Paul, MN
James Vang
Zepto Life Technology, LLC, St. Paul, MN
Victor Brenk
Zepto Life Technology, LLC, St. Paul, MN
Sagar M. Goyal
University of Minnesota, St. Paul, MN
James Collins
University of Minnesota, St. Paul, MN
Paper No:
DMD2017-3375, V001T07A001; 2 pages
Published Online:
October 31, 2017
Citation
Wang, W, Aboubakr, HA, Vang, J, Brenk, V, Goyal, SM, & Collins, J. "Nanomagnetic Biosensor for the Detection of Porcine Interferon Gamma." Proceedings of the 2017 Design of Medical Devices Conference. 2017 Design of Medical Devices Conference. Minneapolis, Minnesota, USA. April 10–13, 2017. V001T07A001. ASME. https://doi.org/10.1115/DMD2017-3375
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