Many surgeons have come to view mitral valve (MV) repair as the treatment of choice in patients with mitral regurgitation (MR) [1]. According to recent long-term studies, the recurrence of significant MR after repair may be much higher than previously believed, particularly in patients with (ischemic mitral regurgitation) IMR [2]. We hypothesize that the restoration of homeostatic normal MV leaflet tissue stress in IMR repair techniques ultimately leads to improved repair durability. Therefore, the objective of this study is to develop a novel micro-anatomically accurate 3D finite element (FE) model that incorporates detailed collagen fiber architecture, accurate constitutive models, and micro-anatomically realistic valvular geometry to investigate the functional mitral valve and to aid in the assessment of the mitral valve repairs, especially the linking between the interstitial cellular deformations at the cellular level, the mechanobiological behaviors at the tissue level and the organ level mechanical responses as normal and repaired mitral valves maintaining their homeostatic state.
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ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation
September 11–13, 2013
Washington, DC, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5600-0
PROCEEDINGS PAPER
A Novel Micro-CT Based Anatomically Accurate Finite Element Model for Simulation-Aided Assessment of Mitral Valve Repairs
Chung-Hao Lee,
Chung-Hao Lee
The University of Texas at Austin, Austin, TX
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Robert C. Gorman,
Robert C. Gorman
The University of Pennsylvania, Philidelphia, PA
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Joseph H. Gorman, III,
Joseph H. Gorman, III
The University of Pennsylvania, Philidelphia, PA
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Rouzbeh Aimini,
Rouzbeh Aimini
University of Pittsburgh, Pittsburgh, PA
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Michael S. Sacks
Michael S. Sacks
The University of Texas at Austin, Austin, TX
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Chung-Hao Lee
The University of Texas at Austin, Austin, TX
Robert C. Gorman
The University of Pennsylvania, Philidelphia, PA
Joseph H. Gorman, III
The University of Pennsylvania, Philidelphia, PA
Rouzbeh Aimini
University of Pittsburgh, Pittsburgh, PA
Michael S. Sacks
The University of Texas at Austin, Austin, TX
Paper No:
FMD2013-16136, V001T10A035; 2 pages
Published Online:
February 19, 2014
Citation
Lee, C, Gorman, RC, Gorman, JH, III, Aimini, R, & Sacks, MS. "A Novel Micro-CT Based Anatomically Accurate Finite Element Model for Simulation-Aided Assessment of Mitral Valve Repairs." Proceedings of the ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. Washington, DC, USA. September 11–13, 2013. V001T10A035. ASME. https://doi.org/10.1115/FMD2013-16136
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