The development of biomimetic materials for osteochondral tissue substitution and repair can be the start for a revolution in the classical procedures of orthopaedic surgery. The persisting problems, linked to the absence of a complete functional recovery of the articulation and to the stabilization and protraction of the half-life of an articular prosthesis can be overcome by the new class of osteochondral substitutes. The characteristics of the artificial bone tissue are drastically different from those of the natural one and this is mainly due to the absence of the peculiar self-organizing interaction between apatite crystals and proteic matrix. At this purpose a biomimetic approach was used in which apatitic phases are directly nucleated on different macromolecular matrices, which act as template and induce peculiar physico-chemical features in the mineral phase to create a substitute for osteochondral lesions. In particular a biologically inspired approach was applied to nucleate bone-like hydroxyapatite (HA) nanocrystals on self-assembling collagen fibers. Biohybrid composite materials were obtained mimicking composition, structure and morphology of human osteochondral interfaces. [1–4]
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ASME 2010 5th Frontiers in Biomedical Devices Conference
September 20–21, 2010
Newport Beach, California, USA
Conference Sponsors:
- Nanotechnology Institute
ISBN:
978-0-7918-4945-3
PROCEEDINGS PAPER
Innovative Biomimetic Hybrid Composites to Repair Multifunctional Anatomical Region Available to Purchase
A. Tampieri,
A. Tampieri
ISTEC-CNR - Institute of Science and Technology for Ceramics-National Research Council, Faenza, RA, Italy
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M. Sandri,
M. Sandri
ISTEC-CNR - Institute of Science and Technology for Ceramics-National Research Council, Faenza, RA, Italy
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T. D’Alessandro,
T. D’Alessandro
ISTEC-CNR - Institute of Science and Technology for Ceramics-National Research Council, Faenza, RA, Italy
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M. Banobre-Lopez,
M. Banobre-Lopez
University of Santiago de Compostela, Santiago de Compostela, Spain
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J. Rivas
J. Rivas
University of Santiago de Compostela, Santiago de Compostela, Spain
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A. Tampieri
ISTEC-CNR - Institute of Science and Technology for Ceramics-National Research Council, Faenza, RA, Italy
M. Sandri
ISTEC-CNR - Institute of Science and Technology for Ceramics-National Research Council, Faenza, RA, Italy
T. D’Alessandro
ISTEC-CNR - Institute of Science and Technology for Ceramics-National Research Council, Faenza, RA, Italy
M. Banobre-Lopez
University of Santiago de Compostela, Santiago de Compostela, Spain
J. Rivas
University of Santiago de Compostela, Santiago de Compostela, Spain
Paper No:
BioMed2010-32059, pp. 13-14; 2 pages
Published Online:
July 16, 2013
Citation
Tampieri, A, Sandri, M, D’Alessandro, T, Banobre-Lopez, M, & Rivas, J. "Innovative Biomimetic Hybrid Composites to Repair Multifunctional Anatomical Region." Proceedings of the ASME 2010 5th Frontiers in Biomedical Devices Conference. ASME 2010 5th Frontiers in Biomedical Devices Conference and Exhibition. Newport Beach, California, USA. September 20–21, 2010. pp. 13-14. ASME. https://doi.org/10.1115/BioMed2010-32059
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