The manipulation of particles in fluids using microfluidic devices is a fundamental task in Lab-on-a-Chip applications. Grooved structures have been widely studied in particle handling and fluid mixing in microfluidic channel systems. In this study, we report use of patterning flows produced by a series of grooved surfaces with different geometrical setups integrated into a microfluidic device, to continuously manipulate the flowing particles, ranging from 6 to 20 μm in diameters, of comparable sizes to the depth of the channel. COMSOL, a multiphysics modeling software that can help predict engineering trends, is used to systematically quantify the following parameters: 1) channel depth, 2) groove width, 3) groove depth, 4) groove angle, and 5) flow speed, which may affect the performance of separation for flowing particles inside the channel. The device is fabricated using softlithographic techniques and is composed of inlets, microfluidic channels, and outlets for loading, manipulating and retrieving cell suspensions, respectively. Experimental results indicated that the particles were evenly distributed in the entrance of the microchannel and illustrate patterns of enriching, focusing, or size-selective profiles after passing through the grooved area. The preliminary simulation results also demonstrated that particles tend to bias towards the sidewall after flowing through the grooves.
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ASME 2009 4th Frontiers in Biomedical Devices Conference
June 8–9, 2009
Irvine, California, USA
Conference Sponsors:
- Nanotechnology Institute
ISBN:
978-0-7918-4348-2
PROCEEDINGS PAPER
Development of a Novel Micro-Manipulation Device and Its Simulation Using COMSOL
Hsiu-hung Chen,
Hsiu-hung Chen
University of Washington, Seattle, WA
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Dayong Gao
Dayong Gao
University of Washington, Seattle, WA
Search for other works by this author on:
Hsiu-hung Chen
University of Washington, Seattle, WA
Dayong Gao
University of Washington, Seattle, WA
Paper No:
BioMed2009-83086, pp. 107-109; 3 pages
Published Online:
February 17, 2010
Citation
Chen, H, & Gao, D. "Development of a Novel Micro-Manipulation Device and Its Simulation Using COMSOL." Proceedings of the ASME 2009 4th Frontiers in Biomedical Devices Conference. ASME 2009 4th Frontiers in Biomedical Devices. Irvine, California, USA. June 8–9, 2009. pp. 107-109. ASME. https://doi.org/10.1115/BioMed2009-83086
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