Computational modeling was performed to study how loss of compliance of the eye and abnormally high pressures result in changes in stresses and strains that may impact the optic nerve in diseases such as glaucoma. Hemispherical finite element models of the eye were created in which scleral thickness varied from the equatorial region to the optic nerve head (ONH). Nonhomogeneous material properties were used to model the ONH as a continuous region softer than the adjacent sclera. The ONH and an adjacent buffer zone in the sclera were modeled with enough detail that the size of the ONH could be changed to account for variations observed in humans. The model was provided with appropriate dimensions typical of patients and nonlinear material properties with decreased compliance. Models with different ONH sizes were inflated in small steps to 55 mmHg (7.33 kPa), providing deformed configurations at intermediate pressures of 15, 30 and 45 mmHg, respectively. Color-coded maps of stress and strain components were rendered directly on deformed configurations of the eye model; and animations were produced that show both spatial and temporal variations of stresses and strains as internal pressure increases. Three-dimensional stresses and accompanying finite strains were similar for ONH sizes ranging form 1.5 to 2.5 mm in diameter. Stress and strain differences were estimated as pressure was increased from 15 to 25 mmHg, 30 to 40 mmHg, and 45 to 55 mmHg. Substantial changes occurred in stress and strain differences as the pressure range was varied with large changes occurring in the lowest pressure range for strain components and moderate increases in stress differences as pressures increase.
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ASME 2008 3rd Frontiers in Biomedical Devices Conference
June 18–20, 2008
Irvine, California, USA
Conference Sponsors:
- Nanotechnology Institute
ISBN:
0-7918-4833-7
PROCEEDINGS PAPER
Computational Mechanics of the Sclera and Optic Nerve Head (ONH): Effects of ONH Size and Pressure Range
Lewis Waldman
,
Lewis Waldman
Insilicomed, Inc., La Jolla, CA
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Crystal Cunanan
,
Crystal Cunanan
Cascade Ophthalmics, Inc., Irvine, CA
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Roy Kerckhoffs
,
Roy Kerckhoffs
University of California at San Diego, La Jolla, CA
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Andrew McCulloch
Andrew McCulloch
University of California at San Diego, La Jolla, CA
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Lewis Waldman
Insilicomed, Inc., La Jolla, CA
Crystal Cunanan
Cascade Ophthalmics, Inc., Irvine, CA
Sanjay Asrani
Duke University, Durham, NC
Roy Kerckhoffs
University of California at San Diego, La Jolla, CA
Andrew McCulloch
University of California at San Diego, La Jolla, CA
Paper No:
BioMed2008-38051, pp. 9-10; 2 pages
Published Online:
June 5, 2009
Citation
Waldman, L, Cunanan, C, Asrani, S, Kerckhoffs, R, & McCulloch, A. "Computational Mechanics of the Sclera and Optic Nerve Head (ONH): Effects of ONH Size and Pressure Range." Proceedings of the ASME 2008 3rd Frontiers in Biomedical Devices Conference. ASME 2008 3rd Frontiers in Biomedical Devices Conference. Irvine, California, USA. June 18–20, 2008. pp. 9-10. ASME. https://doi.org/10.1115/BioMed2008-38051
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