This paper describes a polymer-based shear stress sensor built on catheter for in vivo measurements and potential application in atherosclerosis diagnosis. MEMS shear stress sensor with backside wire bonding has been used to address in vitro applications for micro-scale hemodynamics with high temporal and spatial resolution. However, to assess shear stress in the tortuous and dynamic arterial circulation, we had to develop a new generation of polymer- and catheter-based sensors that are both flexible and deployable. The individual sensor was packaged near the tip of a catheter for intravascular shear stress analysis. The wire bonding and electrode leads were insulated by a film of Parylene C and were connected to the external circuit along the guide-wire. The sensor was deployed through the catheter into the aorta of New Zealand White (NZW) rabbits by the femoral cut-down procedure. Based on the heat transfer principle, the device was able to detect small temperature perturbation in response to the pulsatile flow at ∼200 beats/minutes in the rabbits. The sensor was calibrated in the presence of rabbit blood flow at 37.8°C. We demonstrated the feasibility of translating a polymerbased device for dynamic intravascular measurement with a potential for clinical applications in detecting coronary artery disease and stroke.
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ASME 2008 3rd Frontiers in Biomedical Devices Conference
June 18–20, 2008
Irvine, California, USA
Conference Sponsors:
- Nanotechnology Institute
ISBN:
0-7918-4833-7
PROCEEDINGS PAPER
Polymer-Based Sensors for Dynamic Intravascular Shear Stress Analysis Available to Purchase
Lisong Ai,
Lisong Ai
University of Southern California, Los Angeles, CA
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Hongyu Yu,
Hongyu Yu
University of Southern California, Los Angeles, CA
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Mahsa Rouhanizadeh,
Mahsa Rouhanizadeh
University of Southern California, Los Angeles, CA
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Wakako Takabe,
Wakako Takabe
University of Southern California, Los Angeles, CA
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Ellis Meng,
Ellis Meng
University of Southern California, Los Angeles, CA
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E. S. Kim,
E. S. Kim
University of Southern California, Los Angeles, CA
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Tzung Hsiai
Tzung Hsiai
University of Southern California, Los Angeles, CA
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Lisong Ai
University of Southern California, Los Angeles, CA
Hongyu Yu
University of Southern California, Los Angeles, CA
Mahsa Rouhanizadeh
University of Southern California, Los Angeles, CA
Wakako Takabe
University of Southern California, Los Angeles, CA
Ellis Meng
University of Southern California, Los Angeles, CA
E. S. Kim
University of Southern California, Los Angeles, CA
Tzung Hsiai
University of Southern California, Los Angeles, CA
Paper No:
BioMed2008-38097, pp. 55-57; 3 pages
Published Online:
June 5, 2009
Citation
Ai, L, Yu, H, Rouhanizadeh, M, Takabe, W, Meng, E, Kim, ES, & Hsiai, T. "Polymer-Based Sensors for Dynamic Intravascular Shear Stress Analysis." Proceedings of the ASME 2008 3rd Frontiers in Biomedical Devices Conference. ASME 2008 3rd Frontiers in Biomedical Devices Conference. Irvine, California, USA. June 18–20, 2008. pp. 55-57. ASME. https://doi.org/10.1115/BioMed2008-38097
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