An implantable, single-use miniature infusion pump (MIP) was designed to allow radiotracer injection and functional neuroimaging in freely moving mice. The pump comprises a pressurized reservoir, and a parylene electrothermal valve, which opens to inject tracer through an intravenous catheter into the circulation. A 3-layer 300 μl elastomeric reservoir was built by molding silicone in two-part metal casts. The valve was powered by inductive power transfer from an external 20 cm diameter primary coil to an implanted miniature 8-turn, 1.6 cm diameter Litz-wire secondary coil capable of generating 150 mW at the frequency of 2 MHz.

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