An implantable, single-use miniature infusion pump (MIP) was designed to allow radiotracer injection and functional neuroimaging in freely moving mice. The pump comprises a pressurized reservoir, and a parylene electrothermal valve, which opens to inject tracer through an intravenous catheter into the circulation. A 3-layer 300 μl elastomeric reservoir was built by molding silicone in two-part metal casts. The valve was powered by inductive power transfer from an external 20 cm diameter primary coil to an implanted miniature 8-turn, 1.6 cm diameter Litz-wire secondary coil capable of generating 150 mW at the frequency of 2 MHz.
- Nanotechnology Institute
Implantable Minipump With MEMS Electrothemal Valve for Bolus Injection in Mice
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Givrad, TK, Maarek, JI, Li, PY, Meng, E, Sardesai, N, & Holschneider, DP. "Implantable Minipump With MEMS Electrothemal Valve for Bolus Injection in Mice." Proceedings of the ASME 2008 3rd Frontiers in Biomedical Devices Conference. ASME 2008 3rd Frontiers in Biomedical Devices Conference. Irvine, California, USA. June 18–20, 2008. pp. 35-36. ASME. https://doi.org/10.1115/BioMed2008-38086
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