Cell encapsulation in hydrogels or microcapsules is one of the approaches for providing a biomimetic microenvironment to support cell survival, proliferation and functions. Microcapsules in particular have been used to improve the mass transport properties and ease of delivery through injection. More importantly, the microenvironment in hydrogels or hydrogel microcapsules can be tailored by incorporation of relevant adhesion molecules and growth factors through chemical conjugation and physical encapsulation. These functionalized hydrogels have been shown to effectively influence cell adhesion, proliferation and differentiation. In this study, we describe the preparation and characterization of a novel hydrogel fiber by polyelectrolyte complexation. This unique fiber geometry can be useful for regeneration of cylindrical tissues and for coculture of two different cell types inside and outside the fiber membrane.
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ASME 2007 2nd Frontiers in Biomedical Devices Conference
June 7–8, 2007
Irvine, California, USA
Conference Sponsors:
- Nanotechnology Institute
ISBN:
0-7918-4266-5
PROCEEDINGS PAPER
Novel Hydrogel Microfibers for Tissue Engineering
Kartik Trehan,
Kartik Trehan
Johns Hopkins University, Baltimore, MD
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Christopher Yu,
Christopher Yu
Johns Hopkins University, Baltimore, MD
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Sasha Bakhru,
Sasha Bakhru
Johns Hopkins University, Baltimore, MD
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Hai-Quan Mao
Hai-Quan Mao
Johns Hopkins University, Baltimore, MD
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Kartik Trehan
Johns Hopkins University, Baltimore, MD
Christopher Yu
Johns Hopkins University, Baltimore, MD
Sasha Bakhru
Johns Hopkins University, Baltimore, MD
Hai-Quan Mao
Johns Hopkins University, Baltimore, MD
Paper No:
BioMed2007-38066, pp. 65-66; 2 pages
Published Online:
February 24, 2009
Citation
Trehan, K, Yu, C, Bakhru, S, & Mao, H. "Novel Hydrogel Microfibers for Tissue Engineering." Proceedings of the ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASME 2007 2nd Frontiers in Biomedical Devices. Irvine, California, USA. June 7–8, 2007. pp. 65-66. ASME. https://doi.org/10.1115/BioMed2007-38066
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